Super Ladies, two sisters serving as elite officers of the Esperion Police, fight to stop the evil schemes of the great witch Zalba, who seeks to dominate the universe. The sisters, Carla and Sara, head to Earth to halt Zalba's plans. En route, they are ambushed by Zalba. Carla, taking responsibility as the elder sister, stays behind to confront the enemy alone, allowing Sara to escape to Earth. After that, Carla's whereabouts become unknown. Believing in her sister's survival, Sara continues the battle on Earth—only to come face to face with Garula, a powerful witch who has secretly become Zalba's minion.