Freshly married office lady Misaki, now the wife of her boss, becomes the target of jealousy from female coworkers who spike her drink with "lustful blood." Infected by the substance, Misaki is overwhelmed by uncontrollable desire and begins assaulting random men, performing repeated blowjob sessions filled with dirty talk, culminating in creampie after creampie. Her husband notices her strange behavior and seeks help from a subordinate who knows the blood's weakness, attempting treatments involving full-body wax torture and rough sex, but the infection persists. Ultimately, the husband confronts his wife directly, expressing his love through intense tongue-focused cunnilingus, mutual 69, and passionate rear-entry sex with deep tongue-kissing, reaching a fiery peak of marital passion that finally eradicates the cursed blood.