In the darkness blanketing the city at night, special investigator Ryoko Yabuki becomes entangled in a sinister conspiracy. Receiving an urgent covert mission from headquarters, she is ordered to investigate SKC, a pharmaceutical company conducting illegal human experiments. Posing as a scientist, Ryoko infiltrates the experimental facility to uncover the truth. However, what she discovers inside is a series of unimaginably grotesque experiments. Then, a shocking truth emerges—her own biological father, who had gone in ahead of her, is being held captive as a test subject. Her mission now is clear: rescue her father and gather evidence of the experiments. But she is soon discovered, captured, and sentenced by the researchers to become a test subject for a new experimental drug. Injected with a powerful narcotic designed to replace morphine, her body becomes overwhelmed with intense cravings for pleasure. In this state, the researchers subject her to extreme anal abuse, repeatedly forcing large-volume enemas into her rectum, systematically breaking down both her body and mind. Fighting desperately to retain her sanity, Ryoko struggles through terror and agony. Can she save her father and escape this nightmarish laboratory?